Root > Services > Custom Oligos & Predefined DNA/RNA > Custom DNA > Non-fluorescent labels > 3'- non-nucleosidic oligo modifications

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3'-Non-nucleosidic modifications 5' 3' Internal Cat. no. Comments
3'-Alkyne-Modifier   5-0220-50X For alkyne modification of oligos
3'-Alkyne-modifier-Serinol

3'-Alkyne-Modifier Serinol is used for alkyne modification of oligos that can then be labeled or modified by click chemistry.

3'-DBCO-PEG4   5-0220-53X For copper-free Click reactions
3’-Amino   5-0220-01X For attachment of dyes and modifications
  • Useful for synthesis of oligonucleotides with multiple reporter groups and markers when modifications are introduced at the 5'- and 3'-end
  • No extension by DNA-polymerases during PCR
3'-Chol   5-0220-11X For antisense technology
  • Used in antisense technology
  • The highly lipophilic compound mediates the penetration of oligonucleotides through the cell membrane
3'-Hex   5-0220-23X For blocking
  • Used in antisense technology
  • The highly lipophilic compound mediates the penetration of oligonucleotides through the cell membrane 
3'-Phos   5-0220-21X For ligation
  • Blocks the extension of the 3'-end by polymerases (see also Real-time PCR)
  • 3'-phosphorylated oligonucleotides cannot be ligated by ligases
3’-Puromycin   5-0220-41X For inhibition of protein synthesis
  • Inhibits protein syntheis by mimicking transfer RNA.
  • Blocks peptide elongation during translation
  • Linkage to mRNA results in a peptide-RNA fusion product
3’-Thiol   5-0220-31X For attachment of dyes and immobilisation
  • Useful for attachment to various ligands, such as biotin, alkaline phosphatase or fluorescent dyes.
  • Allows attachment to solid surfaces and immobilisation
*: All Oligos are available in 0.05, 0.2 and 1.0 µmol
**: All modified DNA oligonucleotides are HPLC purified at no additional charge.