Root > Services > Custom Oligos & Predefined DNA/RNA > Custom DNA > Non-fluorescent labels > 5'- non-nucleosidic oligo modifications

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5'-Non-nucleosidic modifications 5' 3' Internal Cat. no. Comments
5'-C9-Alkyne   5-0209-01X For alkyne modification of oligos
5'-C9-Alkyne-CEP

5'-C9-Alkyne is used for alkyne modification of oligos that can then be labeled or modified by click chemistry.

5'-C15-Alkyne   5-0209-02X For alkyne modification of oligos
5'-C15-Alkyne-CEP

5'-C15-Alkyne is used for alkyne modification of oligos that can then be labeled or modified by click chemistry.

5'-Alkyne-PEG3   5-0209-00X For alkyne modification of oligos
5'-Alkyne-PEG3-CEP

5'-Alkyne-PEG3 is used for alkyne modification of oligos that can then be labeled or modified by click chemistry.

5'-DBCO-PEG4   5-0209-10X For copper-free Click reactions
DBCO-PEG4
5'-Amino-C3   5-0210-10X For attachment of dyes and modifications
5aminoc3
  • Primary amino group attached to a 3-carbon spacer
  • Useful for the attachment of fluorescent reporter groups, biotin, digoxigenin, and enzymes or antibodies
  • Used for immobilization of oligonucleotides on solid supports therefore used commonly in DNA arrays and solid-phase PCRs
  • Used when the oligonucleotide must not be spaced far from the corresponding interaction.
5'-Amino-C6   5-0210-11X For attachment of dyes and modifications
5AminoC6
  • Primary amino group attached to a 6-carbon spacer
  • Useful for the attachment of fluorescent reporter groups, biotin,    digoxigenin, and enzymes or antibodies 
  • Used for immobilization of oligonucleotides on solid supports
5'-Amino-C12   5-0210-21X For attachment of dyes and modifications
5AminoC12
  • Primary amino group attached to a 12-carbon spacer
  • Greater spacing between oligonucleotide and reporter groups
  • Can reduce intramolecular quenching of fluorescence
  • Useful for affinity chromatography
5'-Branching (5’-Branch)   5-0210-22X Multiplies attachment sites
5Branching
  • Each coupling doubles the amount of sites used for coupling with modifications
5’-Carboxyl   5-0210-23X For immobilization and coupling
  • Used for immobilization of oligonucleotides on solid supports
  • Used for coupling of oligonucleotides with proteins
5'-Cholesteryl (5’-Chol)   5-0210-31X For antisense technology
5Cholesteryl
  • Useful in antisense technology
  • The highly lipophilic compound facilitates membrane penetration
5'-Hexaethylenglycol (5'-HeGl)   5-0210-41X 18-Atom spacer
5Hexaethylenglycol
  • Hydrophilic spacer
  • Can also be introduced at internal sites
  • In hammerhead ribozymes it can replace the tetra-loop of stem II with essentially no decrease in activity compared with the wild-type ribozyme
5'-Phosphate (5'-Phos)   5-0210-51X For ligation
  • For ligation of PCR products
  • Very high degree of phosphorylation (>95%)
  • Superior to enzymatic methods
5'-Psoralen-C2 (5'-PsorC2)   5-0210-61X For nucleic acid cross-linking
5Psoralen
  • For cross-linking double-stranded oligonucleotides
5'-Psoralen-C6 (5'-PsorC6)   5-0210-71X For cross-linking of triple helices
5Psoralen
  • For cross-linking triple helices
5'-Thiol-C6 (5'-SH)   5-0210-81X For attachment of dyes and immobilisation
5ThiolC6
  • For coupling oligonucleotides with maleimide or iodoacetate activated antibodies, peptides, enzymes or fluorescent dyes
  • Useful for double labelings with different dyes (5'-thiol in combination with internal- or 3'-amino-groups)  
5'-Triethylenglycol (5'-TriGl)   5-0210-91X 9-Atom spacer
5Triethylenglycol
  • Hydrophilic spacer
  • Can also be coupled at internal sites
*: All Oligos are available in 0,05; 0,2; 1,0 µmol
**: All modified DNA oligonucleotides are HPLC purified at no additional charge.