A promising alternative to antibodies
Aptamers are DNA, RNA (or peptide) molecules that show ability to bind to specific target molecules. Due to their specificity, high affinity, low immunogenicity and ease of use, Aptamers have been widely used in medical and industrial fields.
For the generation of new DNA or RNA Aptamers a complete development process consisting of in vitro selection by SELEX, sequence analysis, aptamer characterization and optimization has to be performed.
For this service, IBA has a collaboration with two partners:
Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses (IZI-BB), Dr. M. Menger, is based in Potsdam, Germany and covers the European market.
Once the Aptamer of interest has been found, IBA comes into play. Taking advantage of 20 years of expertise in high quality oligonucleotide synthesis, we offer custom made DNA and RNA Aptamers based on the customers’ specifications. A large selection of modifications and fluorescent labels is available for this service (see links below).
The AptaIndex is a helpful source of known Aptamers, which can be custom synthesized by IBA.
“With Fraunhofer IZI-BB and Aptagen we have found two biotech establishments committed to very high quality standard for their products. Combined with IBAs known expertise in chemical nucleic acid synthesis these collaborations are very promising to attract Aptamer customers” said Dr. Joachim Bertram, managing director at IBA.