A promising alternative to antibodies
Aptamers are DNA, RNA (or peptide) molecules that show the ability to bind to specific target molecules. Due to their specificity, high affinity, low immunogenicity and ease of use, Aptamers have been widely used in medical and industrial fields.
For the generation of new DNA or RNA Aptamers a complete development process consisting of in vitro selection by SELEX, sequence analysis, aptamer characterization and optimization has to be performed.
Taking advantage of 20 years of expertise in high quality oligonucleotide synthesis, IBA offers custom made DNA and RNA Aptamers based on the customers’ specifications.
To order your aptamer of choice get in contact with our individual personal assistance provided by nucleic acid chemists and molecular biologists. Your personal contact person from IBA Lifesciences is ready to help you by email or phone (+49 551 50672-222) and will support you in designing your correct oligo sequence and advise you in possible promising labeling and modification combinations. Furthermore our assistance alerts you to create incorrect not functional oligonucleotides before starting the synthesis.
IBA has a collaboration with various partners, amongst them:
Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses (IZI-BB), Dr. M. Menger, is based in Potsdam, Germany and covers the European market.
In North America, IBA now started to cooperate with the US biotech company Aptagen, LLC in Jacobus, PA. Aptagen is a biotechnology company with over 25 years of experience in the discovery and development of aptamer technology. They provide services to global businesses from research institutions to Top 10 Pharma companies.
“With Fraunhofer IZI-BB and Aptagen we have found two biotech establishments committed to very high quality standard for their products. Combined with IBAs known expertise in chemical nucleic acid synthesis these collaborations are very promising to attract Aptamer customers” said Dr. Joachim Bertram, managing director at IBA.
The AptaIndex is a helpful source of known Aptamers, which can be custom synthesized by IBA.
Long DNAs for aptamer technology
The aptamers laboratory at the IRYCIS-Hospital Ramon y Cajal (Madrid, Spain), led by Dr. Victor M. Gonzalez, uses IBA-synthesized long DNA oligonucleotides to develop new applications for the aptamer technology. "In our laboratory, we are currently taking advance of the performance of IBA technology for the synthesis of long DNA oligonucleotides for the selection and characterization of aptamers against several targets. In fact, we use populations of oligos containing random sequences into the central region synthesized by IBA for aptamer selection. After identification of specific aptamers, we use these long DNA oligos modified with different molecules (Biotin, Digoxigenin, Alexa) at their 5´end to study the application of aptamers in the development of novel diagnostic tools."