3'-Non-nucleosidic modifications

3'-Non-nucleosidic modifications 5' 3' Internal Cat. no. Comments
3'-Alkyne-Modifier   5-0220-50X For alkyne modification of oligos
3'-Alkyne-modifier-Serinol

3'-Alkyne-Modifier Serinol is used for alkyne modification of oligos that can then be labeled or modified by click chemistry.

3'-DBCO-PEG4   5-0220-53X For copper-free Click reactions
3’-Amino   5-0220-01X For attachment of dyes and modifications
  • Useful for synthesis of oligonucleotides with multiple reporter groups and markers when modifications are introduced at the 5'- and 3'-end
  • No extension by DNA-polymerases during PCR
3'-Chol   5-0220-11X For antisense technology
  • Used in antisense technology
  • The highly lipophilic compound mediates the penetration of oligonucleotides through the cell membrane
3'-Hex   5-0220-23X For blocking
  • Used in antisense technology
  • The highly lipophilic compound mediates the penetration of oligonucleotides through the cell membrane 
3'-Phos   5-0220-21X For ligation
  • Blocks the extension of the 3'-end by polymerases (see also Real-time PCR)
  • 3'-phosphorylated oligonucleotides cannot be ligated by ligases
3’-Puromycin   5-0220-41X For inhibition of protein synthesis
  • Inhibits protein syntheis by mimicking transfer RNA.
  • Blocks peptide elongation during translation
  • Linkage to mRNA results in a peptide-RNA fusion product
3’-Thiol   5-0220-31X For attachment of dyes and immobilisation
  • Useful for attachment to various ligands, such as biotin, alkaline phosphatase or fluorescent dyes.
  • Allows attachment to solid surfaces and immobilisation
*: All Oligos are available in 0.05, 0.2 and 1.0 µmol
**: All modified DNA oligonucleotides are HPLC purified at no additional charge.
To order your tailor-made oligo above get in contact with our individual personal assistance provided by nucleic acid chemists and molecular biologists. Your personal contact person from IBA Lifesciences is ready to help you by email or phone (+49 551 50672-222) and will support you in designing your correct oligo sequence and advise you in possible promising labeling and modification combinations. Furthermore our assistance alerts you to create incorrect not functional oligonucleotides before starting the synthesis.