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Immunoprecipitation using Selector Resins

Selector resins are based on high-affinity single-domain antibodies (sdAb) which are covalently immobilized on 4% cross-linked agarose beads. The oriented and selective attachment via a flexible linker guarantees a high accessibility of the sdAbs and largely eliminates batch-to-batch variations. Due to the single-chain nature of sdAbs and their covalent attachment, no "leakage" of light and heavy chains from IgGs is observed during elution with SDS sample buffer.

Choose from our Selector Portfolio:

Comparison of conventional immunoprecipitation with Selector Resins
Conventional IP using antibodies versus IP with Selector Resins

Key Benefits of Selector Resins

  • High capacity
  • Minimal unspecific binding
  • No co-elution of heavy and light chain
  • Broad buffer compatibility for high flexibility